Macrophages in leukemia microenvironment
نویسندگان
چکیده
منابع مشابه
Abnormal Function of the Bone Marrow Microenvironment in Chronic Myelogenous Leukemia: Role of Malignant Stromal Macrophages
The bone marrow microenvironment supports and regulates the proliferation and differentiation of hematopoietic cells. Dysregulated hematopoiesis in chronic myelogenous leukemia (CML) is caused, at least in part, by abnormalities in CML hematopoietic progenitors leading to altered interactions with the marrow microenvironment. The role of the microenvironment itself in CML has not been well char...
متن کاملAbnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages.
The bone marrow microenvironment supports and regulates the proliferation and differentiation of hematopoietic cells. Dysregulated hematopoiesis in chronic myelogenous leukemia (CML) is caused, at least in part, by abnormalities in CML hematopoietic progenitors leading to altered interactions with the marrow microenvironment. The role of the microenvironment itself in CML has not been well char...
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Macrophages and the tumor microenvironment Tumor tissue comprises a highly complex network of diverse cell types. In a simplified view, the tumor microenvironment can be subdivided into the cancer cell and the stromal cell compartments, the latter of which harbors many different cell types. A considerable number of innate immune cells reside within the tumor microenvironment, including macropha...
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We showed previously that tumor-derived supernatant (TSN) from acute myeloid leukemia (AML) myeloblasts inhibits peripheral blood T cell activation and proliferation, rendering the T cells functionally incompetent. We show here that the AML TSN also significantly delays apoptosis of both resting and stimulated T cells, as judged by reduction in annexin V/propidium iodide staining. In addition, ...
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Distinct tumor microenvironment forms in each progression step of cancer and has diverse capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now known that immune cells can be activated to favor tumor growth and progression, most probably influenced by the tumor microenvironment. Tumor-associated macrophages and tumor-associated neutrophils can exert protumora...
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ژورنال
عنوان ژورنال: Blood Science
سال: 2019
ISSN: 2543-6368,2543-6368
DOI: 10.1097/bs9.0000000000000014